{"id":664238,"date":"2025-12-02T07:36:04","date_gmt":"2025-12-02T07:36:04","guid":{"rendered":"https:\/\/microscopemedia.com\/?p=664238"},"modified":"2025-12-02T07:36:04","modified_gmt":"2025-12-02T07:36:04","slug":"studiu-un-tratament-experimental-pentru-cancer-dezvaluie-efecte-anti-imbatranire-care-ii-surprind-pe-cercetatori","status":"publish","type":"post","link":"https:\/\/microscopemedia.com\/?p=664238","title":{"rendered":"Studiu: Un tratament experimental pentru cancer dezv\u0103luie efecte anti-\u00eemb\u0103tr\u00e2nire care \u00eei surprind pe cercet\u0103tori"},"content":{"rendered":"
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Cercet\u0103torii de la Facultatea de \u0218tiin\u021be Biologice \u0219i Comportamentale a Universit\u0103\u021bii Queen Mary din Londra au descoperit efecte anti-\u00eemb\u0103tr\u00e2nire surprinz\u0103toare ale unui medicament oncologic de genera\u021bie nou\u0103, ar\u0103t\u00e2nd c\u0103 inhibitorul TOR rapalink-1 poate extinde semnificativ durata de via\u021b\u0103 a drojdiei de fisiune, conform SciTechDaily<\/a><\/span>.<\/p>\n

Studiul, publicat \u00een Communications Biology<\/a><\/span>, sugereaz\u0103 c\u0103 tratamentele concepute pentru cancer pot influen\u021ba \u0219i procesul de \u00eemb\u0103tr\u00e2nire prin c\u0103i metabolice \u00eenc\u0103 neexplorate.<\/p>\n

Inhibitor avansat TOR care prelunge\u0219te via\u021ba celulelor<\/h2>\n

Rapalink-1, creat ini\u021bial ca tratament promi\u021b\u0103tor \u00eempotriva cancerului, s-a dovedit c\u0103 \u00eencetine\u0219te \u00eemb\u0103tr\u00e2nirea drojdiei ac\u021bion\u00e2nd asupra TORC1, partea din calea TOR care controleaz\u0103 cre\u0219terea celular\u0103.<\/p>\n

Cercet\u0103torii au constatat c\u0103 medicamentul reduce func\u021biile de cre\u0219tere celular\u0103, stimul\u00e2nd \u00een acela\u0219i timp longevitatea \u0219i eviden\u021biind compromisurile mecanice tipice biologiei \u00eemb\u0103tr\u00e2nirii.<\/p>\n

Una dintre descoperirile majore ale studiului este rolul nea\u0219teptat al agmatinelor (enzime care transform\u0103 metabolitul agmatin\u0103 \u00een poliamine).<\/p>\n

Aceste enzime fac parte dintr-un nou \u201ecircuit metabolic de feedback\u201d care regleaz\u0103 activitatea TOR.<\/p>\n

C\u00e2nd activitatea agmatinelor a fost perturbat\u0103, celulele s-au multiplicat mai rapid, dar au prezentat semne de \u00eemb\u0103tr\u00e2nire timpurie, subliniind echilibrul fragil dintre cre\u0219terea accelerat\u0103 \u0219i s\u0103n\u0103tatea celular\u0103 pe termen lung.<\/p>\n

Metaboli\u021bi \u0219i suplimente cu efecte similare asupra longevit\u0103\u021bii<\/h2>\n

Echipa a demonstrat, de asemenea, c\u0103 administrarea de metaboli\u021bi precum agmatina sau putrescina prelunge\u0219te durata de via\u021b\u0103 a drojdiei \u00een anumite condi\u021bii metabolice.<\/p>\n

Aceasta sugereaz\u0103 c\u0103 at\u00e2t medicamentele, c\u00e2t \u0219i compu\u0219ii naturali pot influen\u021ba \u00eemb\u0103tr\u00e2nirea prin aceea\u0219i cale biochimic\u0103.<\/p>\n

Autorii avertizeaz\u0103 totu\u0219i c\u0103 suplimentele de agmatin\u0103, deja disponibile pe pia\u021b\u0103, trebuie utilizate cu pruden\u021b\u0103, deoarece efectele benefice apar doar dac\u0103 anumite c\u0103i metabolice sunt intacte, iar agmatina poate contribui uneori la patologii.<\/p>\n

Implica\u021bii pentru \u00eemb\u0103tr\u00e2nirea uman\u0103, nutri\u021bie \u0219i cercetarea cancerului<\/h2>\n

Pentru c\u0103 mecanismul TOR func\u021bioneaz\u0103 similar de la drojdie p\u00e2n\u0103 la oameni, aceste descoperiri ar putea influen\u021ba viitoarele strategii privind \u00eemb\u0103tr\u00e2nirea s\u0103n\u0103toas\u0103, tratamentele oncologice \u0219i bolile metabolice.<\/p>\n

Studiul \u00eent\u0103re\u0219te leg\u0103tura \u0219tiin\u021bific\u0103 dintre diet\u0103, microbiom \u0219i longevitate, ar\u0103t\u00e2nd cum circuitele metabolice pot controla \u00eemb\u0103tr\u00e2nirea la nivel celular.<\/p>\n","protected":false},"excerpt":{"rendered":"

Cercet\u0103torii de la Facultatea de \u0218tiin\u021be Biologice \u0219i Comportamentale a Universit\u0103\u021bii Queen Mary din Londra au descoperit efecte anti-\u00eemb\u0103tr\u00e2nire surprinz\u0103toare ale unui medicament oncologic de genera\u021bie nou\u0103, ar\u0103t\u00e2nd c\u0103 inhibitorul … Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":664239,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/posts\/664238"}],"collection":[{"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=664238"}],"version-history":[{"count":0,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/posts\/664238\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/media\/664239"}],"wp:attachment":[{"href":"https:\/\/microscopemedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=664238"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=664238"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=664238"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}