{"id":667391,"date":"2025-12-21T03:46:05","date_gmt":"2025-12-21T03:46:05","guid":{"rendered":"https:\/\/microscopemedia.com\/?p=667391"},"modified":"2025-12-21T03:46:05","modified_gmt":"2025-12-21T03:46:05","slug":"serotonina-si-simptomele-negative-ale-schizofreniei-descoperirea-care-poate-schimba-tratamentul","status":"publish","type":"post","link":"https:\/\/microscopemedia.com\/?p=667391","title":{"rendered":"Serotonina \u0219i simptomele negative ale schizofreniei. Descoperirea care poate schimba tratamentul"},"content":{"rendered":"
<\/div>\n

 Aceste manifest\u0103ri afecteaz\u0103 profund calitatea vie\u021bii \u0219i, p\u00e2n\u0103 acum, nu au r\u0103spuns la niciun tratament medicamentos eficient.<\/p>\n

Un nou studiu realizat de cercet\u0103tori de la King\u2019s College London aduce \u00eens\u0103 o explica\u021bie biologic\u0103 solid\u0103, concentr\u00e2ndu-se pe rolul serotoninei \u0219i simptomelor negative ale schizofreniei. Cercetarea, publicat\u0103 \u00een prestigioasa revist\u0103 JAMA Psychiatry, ofer\u0103 primele dovezi directe, ob\u021binute la pacien\u021bi vii, care leag\u0103 eliberarea excesiv\u0103 de serotonin\u0103 de severitatea simptomelor negative.<\/p>\n

Cum a fost realizat studiul despre serotonin\u0103 \u0219i simptomele negative ale schizofreniei<\/h2>\n

Studiul a inclus 54 de adul\u021bi, dintre care 26 diagnostica\u021bi cu schizofrenie \u0219i 28 persoane s\u0103n\u0103toase, utilizate ca grup de control. Participan\u021bii au fost supu\u0219i la dou\u0103 scan\u0103ri PET, folosind un radiotrasor care se leag\u0103 de receptorii serotoninei de tip 2A. \u00centre cele dou\u0103 scan\u0103ri, subiec\u021bii au primit o doz\u0103 de d-amfetamin\u0103, substan\u021b\u0103 care stimuleaz\u0103 eliberarea de serotonin\u0103.<\/p>\n

Rezultatele au ar\u0103tat c\u0103, de\u0219i to\u021bi participan\u021bii au prezentat o cre\u0219tere a serotoninei, pacien\u021bii cu schizofrenie au avut o eliberare semnificativ mai mare, \u00een special \u00een cortexul frontal \u2014 zona creierului responsabil\u0103 de motiva\u021bie, luarea deciziilor \u0219i comportamentul orientat spre scop.<\/p>\n

Leg\u0103tura direct\u0103 dintre serotonin\u0103 \u0219i simptomele negative ale schizofreniei<\/h2>\n

Analiza datelor a indicat o corela\u021bie clar\u0103: cu c\u00e2t eliberarea de serotonin\u0103 era mai mare, cu at\u00e2t simptomele negative ale schizofreniei erau mai severe. Pacien\u021bii afecta\u021bi prezentau dificult\u0103\u021bi majore \u00een via\u021ba de zi cu zi, inclusiv lipsa independen\u021bei, izolarea social\u0103 \u0219i imposibilitatea de a desf\u0103\u0219ura activit\u0103\u021bi obi\u0219nuite.<\/p>\n

Efectul a fost deosebit de pronun\u021bat la pacien\u021bii cu a\u0219a-numita \u201eschizofrenie deficitar\u0103\u201d, o form\u0103 caracterizat\u0103 prin simptome negative persistente. Important este faptul c\u0103 rezultatele s-au men\u021binut chiar \u0219i dup\u0103 excluderea pacien\u021bilor care urmau tratament antipsihotic, suger\u00e2nd c\u0103 dereglarile serotoninei sunt o tr\u0103s\u0103tur\u0103 intrinsec\u0103 a bolii, nu un efect secundar al medica\u021biei.<\/p>\n

De ce descoperirea este crucial\u0103<\/h2>\n

\u00cen prezent, majoritatea medicamentelor pentru schizofrenie vizeaz\u0103 dopamina, fiind eficiente \u00een reducerea halucina\u021biilor, dar aproape inutile pentru simptomele negative. Descoperirea faptului c\u0103 problema nu este num\u0103rul receptorilor de serotonin\u0103, ci comportamentul anormal al sistemului de eliberare, deschide calea c\u0103tre terapii complet noi.<\/p>\n

Cercet\u0103torii avertizeaz\u0103 c\u0103 sunt necesare studii suplimentare pentru a testa dac\u0103 reglarea sigur\u0103 a serotoninei poate ameliora simptomele negative f\u0103r\u0103 a agrava alte manifest\u0103ri ale bolii. Cu toate acestea, studiul ofer\u0103, pentru prima dat\u0103 \u00een ultimele decenii, un \u021bint biologic clar, acolo unde anterior existau doar ipoteze.<\/p>\n","protected":false},"excerpt":{"rendered":"

 Aceste manifest\u0103ri afecteaz\u0103 profund calitatea vie\u021bii \u0219i, p\u00e2n\u0103 acum, nu au r\u0103spuns la niciun tratament medicamentos eficient. Un nou studiu realizat de cercet\u0103tori de la King\u2019s College London aduce \u00eens\u0103 … Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":667392,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/posts\/667391"}],"collection":[{"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=667391"}],"version-history":[{"count":0,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/posts\/667391\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/media\/667392"}],"wp:attachment":[{"href":"https:\/\/microscopemedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=667391"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=667391"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=667391"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}