{"id":668419,"date":"2025-12-27T09:16:05","date_gmt":"2025-12-27T09:16:05","guid":{"rendered":"https:\/\/microscopemedia.com\/?p=668419"},"modified":"2025-12-27T09:16:05","modified_gmt":"2025-12-27T09:16:05","slug":"studiu-munca-de-noapte-creste-riscul-de-cancer","status":"publish","type":"post","link":"https:\/\/microscopemedia.com\/?p=668419","title":{"rendered":"Studiu: Munca de noapte cre\u0219te riscul de cancer"},"content":{"rendered":"
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Munca \u00een ture de noapte poate duce la cancer mamar agresiv. Un studiu al Universit\u0103\u021bii Texas A&M face lumin\u0103 asupra leg\u0103turii dintre perturbarea ritmului circadian \u0219i progresia cancerului.<\/p>\n

Perturbarea ceasului biologic favorizeaz\u0103 cancerul<\/strong><\/h2>\n

Cercet\u0103torii au descoperit c\u0103 ritmurile circadiene perturbate modific\u0103 structura glandelor mamare \u0219i sl\u0103besc ap\u0103rarea imunitar\u0103. Modelele cu ritm circadian perturbat au dezvoltat cancer la 18 s\u0103pt\u0103m\u00e2ni, fa\u021b\u0103 de 22 s\u0103pt\u0103m\u00e2ni \u00een condi\u021bii normale.<\/p>\n

Tumorile au fost mult mai agresive \u0219i s-au r\u0103sp\u00e2ndit la pl\u0103m\u00e2ni. Sistemul imunitar a fost activ restric\u021bionat, cre\u00e2nd condi\u021bii favorabile pentru supravie\u021buirea celulelor canceroase<\/a>.<\/p>\n

LILRB4: comutatorul de oprire al sistemului imunitar<\/strong><\/h2>\n

Cercet\u0103torii au identificat o molecul\u0103 cheie: receptorul LILRB4. Acesta ac\u021bioneaz\u0103 ca un punct de control imunitar. \u00cen cazul cancerului, LILRB4 devine periculos \u0219i suprim\u0103 r\u0103spunsul imun.<\/p>\n

\u201eLILRB4 ac\u021bioneaz\u0103 ca un comutator de oprire al sistemului imunitar\u201d, a spus dr. Tapasree Roy Sarkar, conduc\u0103torul studiului. C\u00e2nd cercet\u0103torii au \u021bintit LILRB4, micromediul tumoral a devenit mai pu\u021bin imunosupresiv.<\/p>\n

Blocarea LILRB4 reduce metastazele<\/strong><\/h2>\n

Dezactivarea acestui punct de control imunitar a redat sistemului capacitatea de a riposta. Chiar \u0219i \u00een condi\u021bii circadiene perturbate, r\u0103sp\u00e2ndirea cancerului a sc\u0103zut semnificativ.<\/p>\n

\u201eAm observat o reducere semnificativ\u0103 a metastazelor canceroase \u0219i a cre\u0219terii tumorale\u201d, a explicat Sarkar.<\/p>\n

12-35% dintre americani, expu\u0219i riscului<\/strong><\/h2>\n

Se estimeaz\u0103 c\u0103 12-35% dintre americani lucreaz\u0103 \u00een ture neregulate. Ace\u0219tia includ lucr\u0103tori \u00een tura de noapte, \u00eenso\u021bitori de zbor \u0219i c\u0103l\u0103tori frecven\u021bi.<\/p>\n

Perturbarea cronic\u0103 a ritmului circadian nu doar coreleaz\u0103 cu riscul de cancer, ci poate determina activ progresia bolii. Studiul ofer\u0103 unele dintre cele mai puternice dovezi \u00een acest sens.<\/p>\n

Noi strategii terapeutice<\/strong><\/h2>\n

Descoperirea deschide u\u0219i c\u0103tre terapii \u021bintite pentru pacien\u021bii expu\u0219i la risc circadian cronic. Urm\u0103torul obiectiv al cercet\u0103torilor este s\u0103 \u00een\u021beleag\u0103 cum pot inversa efectele perturb\u0103rii circadiene la oameni.<\/p>\n

\u201eAcest studiu redefine\u0219te somnul \u0219i sincronizarea ca factori puternici \u00een progresia \u0219i tratamentul cancerului\u201d, a concluzionat Sarkar.<\/p>\n

Studiul a fost publicat \u00een revista Nature Oncogene<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Munca \u00een ture de noapte poate duce la cancer mamar agresiv. Un studiu al Universit\u0103\u021bii Texas A&M face lumin\u0103 asupra leg\u0103turii dintre perturbarea ritmului circadian \u0219i progresia cancerului. Perturbarea ceasului … Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":668420,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/posts\/668419"}],"collection":[{"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=668419"}],"version-history":[{"count":0,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/posts\/668419\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/media\/668420"}],"wp:attachment":[{"href":"https:\/\/microscopemedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=668419"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=668419"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=668419"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}