{"id":669477,"date":"2026-01-03T06:16:05","date_gmt":"2026-01-03T06:16:05","guid":{"rendered":"https:\/\/microscopemedia.com\/?p=669477"},"modified":"2026-01-03T06:16:05","modified_gmt":"2026-01-03T06:16:05","slug":"descoperire-istorica-in-medicina-cercetatorii-au-creat-un-plaman-uman-care-respira-pe-un-cip-din-celulele-unei-singure-persoane","status":"publish","type":"post","link":"https:\/\/microscopemedia.com\/?p=669477","title":{"rendered":"Descoperire istoric\u0103 \u00een medicin\u0103: Cercet\u0103torii au creat un pl\u0103m\u00e2n uman \u201ecare respir\u0103\u201d pe un cip, din celulele unei singure persoane"},"content":{"rendered":"
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Oamenii de \u0219tiin\u021b\u0103 au realizat primul model de pl\u0103m\u00e2n uman pe cip construit integral din celulele unui singur individ, capabil s\u0103 imite respira\u021bia real\u0103, scrie ScienceBlog<\/a><\/span>.<\/p>\n

Dispozitivul a fost dezvoltat de cercet\u0103tori de la Francis Crick Institute, \u00een colaborare cu compania de biotehnologie AlveoliX, \u0219i reproduce \u00een laborator expansiunea \u0219i contrac\u021bia ritmic\u0103 a pl\u0103m\u00e2nilor umani.<\/p>\n

Un pl\u0103m\u00e2n care respir\u0103 \u0219i se comport\u0103 ca unul real<\/h2>\n

Spre deosebire de modelele anterioare de pl\u0103m\u00e2n pe cip, acest sistem nu r\u0103m\u00e2ne static.<\/p>\n

O membran\u0103 sub\u021bire \u0219i flexibil\u0103 este \u00eentins\u0103 mecanic \u00een trei dimensiuni, simul\u00e2nd mi\u0219c\u0103rile respira\u021biei.<\/p>\n

Aceast\u0103 mi\u0219care fizic\u0103 stimuleaz\u0103 celulele pulmonare s\u0103 formeze microvili, structuri minuscule care m\u0103resc suprafa\u021ba \u0219i sunt esen\u021biale pentru schimbul corect de gaze.<\/p>\n

\u00cen mod crucial, fiecare celul\u0103 din sistem (celulele care c\u0103ptu\u0219esc c\u0103ile respiratorii, celulele vaselor de s\u00e2nge \u0219i macrofagele imune) provine din celule stem ale aceluia\u0219i donator.<\/p>\n

Modelele anterioare combinau celule de la mai mul\u021bi donatori, cre\u00e2nd amestecuri genetice care limitau studiul precis al r\u0103spunsurilor individuale la boal\u0103.<\/p>\n

Leziunile provocate de tuberculoz\u0103, vizibile \u00een zile, nu \u00een luni<\/h2>\n

Pentru a testa sistemul, cercet\u0103torii au introdus bacteria tuberculozei, o boal\u0103 care, de obicei, are nevoie de luni pentru a produce simptome la pacien\u021bi.<\/p>\n

\u00cen interiorul cipului, celulele imune au \u00eenconjurat rapid bacteriile, form\u00e2nd agregate cu nuclee necrotice, un semn clasic al stadiilor timpurii ale tuberculozei.<\/p>\n

\u00cen doar cinci zile, at\u00e2t bariera sacilor de aer, c\u00e2t \u0219i c\u0103ptu\u0219eala vaselor de s\u00e2nge s-au pr\u0103bu\u0219it, nu din cauza unei multiplic\u0103ri rapide a bacteriilor, ci pentru c\u0103 r\u0103spunsul imun a distrus structura pl\u0103m\u00e2nului.<\/p>\n

Acest tip de deteriorare timpurie a fost, p\u00e2n\u0103 acum, aproape imposibil de observat direct la oameni.<\/p>\n

Spre tratamente personalizate pentru bolile pulmonare<\/h2>\n

De asemenea, echipa a modificat cipul prin dezactivarea unei gene implicate \u00een autorepararea celular\u0103.<\/p>\n

\u00cen timpul infec\u021biei, celulele imune au murit mai repede, iar deteriorarea vaselor de s\u00e2nge a fost mai sever\u0103, \u00een ciuda unor niveluri similare de bacterii.<\/p>\n

Descoperirea subliniaz\u0103 rolul geneticii \u00een supravie\u021buirea \u021besuturilor \u00een timpul infec\u021biilor.<\/p>\n

Potrivit cercet\u0103torilor, \u00een viitor, cipurile pulmonare personalizate ar putea ajuta medicii s\u0103 testeze tratamentele \u00eenainte de prescriere.<\/p>\n

Studiul, publicat \u00een Science Advances<\/a><\/span>, deschide totodat\u0103 calea reducerii testelor pe animale \u0219i \u00eembun\u0103t\u0103\u021birii medicinei de precizie \u00een bolile pulmonare.<\/p>\n","protected":false},"excerpt":{"rendered":"

Oamenii de \u0219tiin\u021b\u0103 au realizat primul model de pl\u0103m\u00e2n uman pe cip construit integral din celulele unui singur individ, capabil s\u0103 imite respira\u021bia real\u0103, scrie ScienceBlog. Dispozitivul a fost dezvoltat … Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":669478,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/posts\/669477"}],"collection":[{"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=669477"}],"version-history":[{"count":0,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/posts\/669477\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/media\/669478"}],"wp:attachment":[{"href":"https:\/\/microscopemedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=669477"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=669477"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=669477"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}