{"id":682982,"date":"2026-03-20T14:06:04","date_gmt":"2026-03-20T14:06:04","guid":{"rendered":"https:\/\/microscopemedia.com\/?p=682982"},"modified":"2026-03-20T14:06:04","modified_gmt":"2026-03-20T14:06:04","slug":"sangele-de-piton-ar-putea-revolutiona-tratamentele-de-slabit-dupa-descoperirea-glp-1-cu-ajutorul-unei-specii-de-soparla","status":"publish","type":"post","link":"https:\/\/microscopemedia.com\/?p=682982","title":{"rendered":"S\u00e2ngele de piton ar putea revolu\u021biona tratamentele de sl\u0103bit, dup\u0103 descoperirea GLP-1 cu ajutorul unei specii de \u0219op\u00e2rla"},"content":{"rendered":"
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Pitonii au un metabolism extrem. Pot trece luni \u00eentregi f\u0103r\u0103 s\u0103 m\u0103n\u00e2nce nimic, apoi devoreaz\u0103 o antilop\u0103 \u00eentreag\u0103. \u00cen timp ce acest fel de \u201edieta yo-yo\u201d ar fi dezastruoas\u0103 pentru alte animale, \u0219erpii au adapt\u0103ri speciale care \u00eei ajut\u0103 s\u0103 prospere \u00een stilul lor de via\u021b\u0103 cu boom \u0219i pauz\u0103,<\/strong> noteaz\u0103 Science Alert<\/a>.<\/p>\n

Metabolismul lor se accelereaz\u0103 de 40 de ori dup\u0103 o mas\u0103, inima poate cre\u0219te cu p\u00e2n\u0103 la 24,5% la unele specii, iar microbiomul intestinal este preg\u0103tit s\u0103 reac\u021bioneze imediat la o mas\u0103 rar\u0103.<\/p>\n

Este vorba despre produsele secundare ale acestor bacterii pe care oamenii de \u0219tiin\u021b\u0103 sper\u0103 s\u0103 le valorifice pentru uz uman<\/strong>. Biologii Leslie Leinwand de la Universitatea din Colorado Boulder \u0219i Jonathon Long de la Stanford University au colaborat pentru a afla ce se g\u0103se\u0219te \u00een s\u00e2ngele pitonilor regius \u0219i pitonilor birmanezi dup\u0103 mas\u0103.<\/p>\n

S-au identificat 208 metaboli\u021bi diferi\u021bi care au crescut semnificativ dup\u0103 mesele lunare ale pitonilor, dar unul a atras aten\u021bia cercet\u0103torilor. Nivelurile de para-tiramin\u0103-O-sulfat (pTOS) au crescut de 1.000 de ori \u00een s\u00e2ngele pitonilor dup\u0103 mas\u0103.<\/strong><\/p>\n

Acest metabolit este produs de bacteriile intestinale ale \u0219arpelui \u00een timp ce descompun aminoacidul comun tirozina, eliber\u00e2nd dioxid de carbon \u0219i ad\u0103ug\u00e2nd sulfat moleculei.<\/p>\n

Cercet\u0103torii sudiaz\u0103 acum pTOS<\/h2>\n

Despre pTOS se \u0219tie foarte pu\u021bin. Cercet\u0103torii au g\u0103sit c\u00e2teva studii care sugereaz\u0103 c\u0103 pTOS circul\u0103 \u0219i \u00een corpul uman \u0219i c\u00e2teva indicii c\u0103 nivelul s\u0103u poate cre\u0219te dup\u0103 mas\u0103.<\/p>\n

Acest lucru nu este suficient pentru a spune ce efect are asupra oamenilor, dar a fost de ajuns pentru a inspira cercet\u0103torii s\u0103 investigheze mai departe.<\/p>\n

\u201eDac\u0103 vrem cu adev\u0103rat s\u0103 \u00een\u021belegem metabolismul<\/a>, trebuie s\u0103 mergem dincolo de studiile pe \u0219oareci \u0219i oameni \u0219i s\u0103 ne uit\u0103m la extremele metabolice pe care le ofer\u0103 natura\u201d, spune Long.<\/p>\n

Pierdere \u00een greutate f\u0103r\u0103 efecte secundare?<\/h2>\n

S-a constatat c\u0103, de\u0219i pTOS nu pare s\u0103 apar\u0103 natural la \u0219oareci sau \u0219obolani (animalele cel mai des folosite pentru studii), acesta le afecteaz\u0103 apetitul.<\/p>\n

At\u00e2t \u0219oarecii obezi, c\u00e2t \u0219i cei slabi au consumat mult mai pu\u021bin\u0103 hran\u0103 dup\u0103 ce li s-au administrat doze mari de pTOS,<\/strong> fie prin injec\u021bie abdominal\u0103, fie oral. Pierderea \u00een greutate a survenit f\u0103r\u0103 probleme gastrointestinale, pierdere muscular\u0103 sau sc\u0103deri de energie, efecte frecvent \u00eent\u00e2lnite la alte tratamente.<\/p>\n

At\u00e2t la \u0219oareci, c\u00e2t \u0219i la pitoni, o doz\u0103 de pTOS a activat neuroni \u00een hipotalamusul ventromedial, centrul cerebral care controleaz\u0103 sa\u021bietatea, foamea \u0219i echilibrul energetic, explic\u00e2nd modul \u00een care molecula semnaleaz\u0103 pitonului c\u0103 nu are nevoie s\u0103 m\u0103n\u00e2nce \u00eentreaga antilop\u0103.<\/p>\n","protected":false},"excerpt":{"rendered":"

Pitonii au un metabolism extrem. Pot trece luni \u00eentregi f\u0103r\u0103 s\u0103 m\u0103n\u00e2nce nimic, apoi devoreaz\u0103 o antilop\u0103 \u00eentreag\u0103. \u00cen timp ce acest fel de \u201edieta yo-yo\u201d ar fi dezastruoas\u0103 pentru … Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":682983,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/posts\/682982"}],"collection":[{"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=682982"}],"version-history":[{"count":0,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/posts\/682982\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/media\/682983"}],"wp:attachment":[{"href":"https:\/\/microscopemedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=682982"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=682982"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=682982"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}