{"id":704219,"date":"2026-07-22T01:46:03","date_gmt":"2026-07-22T01:46:03","guid":{"rendered":"https:\/\/microscopemedia.com\/?p=704219"},"modified":"2026-07-22T01:46:03","modified_gmt":"2026-07-22T01:46:03","slug":"cercetatorii-fac-progrese-in-tratarea-uneia-dintre-cele-mai-grave-complicatii-ale-cancerului","status":"publish","type":"post","link":"https:\/\/microscopemedia.com\/?p=704219","title":{"rendered":"Cercet\u0103torii fac progrese \u00een tratarea uneia dintre cele mai grave complica\u021bii ale cancerului"},"content":{"rendered":"
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Cercet\u0103torii spun c\u0103 au f\u0103cut progrese importante \u00een \u00een\u021belegerea mecanismelor care provoac\u0103 aceast\u0103 afec\u021biune, iar primele medicamente dedicate au ajuns deja \u00een studii clinice avansate, se arat\u0103 \u00eentr-o analiz\u0103 publicat\u0103 mar\u021bi \u00een jurnalul Nature.<\/p>\n

Ca\u0219exia afecteaz\u0103 \u00eentre 50% \u0219i 80% dintre pacien\u021bii cu cancer<\/a>, \u00een func\u021bie de tipul tumorii \u0219i de stadiul bolii. Ea nu \u00eenseamn\u0103 doar pierdere \u00een greutate, ci \u0219i degradarea masei musculare, lipsa poftei de m\u00e2ncare, oboseal\u0103 extrem\u0103 \u0219i sc\u0103derea capacit\u0103\u021bii organismului de a suporta tratamente precum chimioterapia sau radioterapia.<\/p>\n

Cercet\u0103torii au descoperit c\u0103 \u00eentregul organism este afectat<\/h2>\n

P\u00e2n\u0103 de cur\u00e2nd, speciali\u0219tii considerau c\u0103 aceast\u0103 stare este cauzat\u0103 \u00een principal de alimenta\u021bia insuficient\u0103 \u0219i de evolu\u021bia cancerului. Noile cercet\u0103ri arat\u0103 \u00eens\u0103 c\u0103 este vorba despre un proces complex, \u00een care tumora declan\u0219eaz\u0103 reac\u021bii inflamatorii \u0219i modific\u0103ri metabolice ce implic\u0103 mai multe organe.<\/p>\n

Ficatul, mu\u0219chii, oasele \u0219i chiar creierul comunic\u0103 \u00eentre ele printr-o re\u021bea de semnale biologice care accelereaz\u0103 degradarea organismului. Aceste descoperiri schimb\u0103 modul \u00een care medicii privesc una dintre cele mai dificile complica\u021bii ale bolii.<\/p>\n

Creierul are un rol important<\/h2>\n

Oamenii de \u0219tiin\u021b\u0103 au identificat un rol esen\u021bial al proteinei GDF15, care transmite creierului senza\u021bia de sa\u021bietate \u0219i reduce apetitul. La pacien\u021bii cu cancer, nivelurile ridicate ale acestei proteine contribuie la lipsa poftei de m\u00e2ncare \u0219i la pierderea rapid\u0103 \u00een greutate.<\/p>\n

\u00cen acela\u0219i timp, inflama\u021bia reduce produc\u021bia de dopamin\u0103, substan\u021ba responsabil\u0103 de motiva\u021bie. Din acest motiv, mul\u021bi pacien\u021bi nu doar c\u0103 sunt sl\u0103bi\u021bi fizic, ci \u00ee\u0219i pierd \u0219i dorin\u021ba de a m\u00e2nca, de a face mi\u0219care sau chiar de a continua tratamentul.<\/p>\n

Primele rezultate \u00eencurajatoare ale unui tratament<\/h2>\n

Cele mai promi\u021b\u0103toare rezultate vin din testarea unui anticorp care blocheaz\u0103 proteina GDF15.<\/p>\n

\u00centr-un studiu clinic desf\u0103\u0219urat pe 187 de pacien\u021bi, cei care au primit cea mai mare doz\u0103 au c\u00e2\u0219tigat peste dou\u0103 kilograme \u00een decurs de 12 s\u0103pt\u0103m\u00e2ni, \u00een timp ce pacien\u021bii trata\u021bi cu placebo au continuat s\u0103 piard\u0103 \u00een greutate.<\/p>\n

Participan\u021bii au raportat, de asemenea, o cre\u0219tere a poftei de m\u00e2ncare \u0219i o \u00eembun\u0103t\u0103\u021bire a nivelului de activitate fizic\u0103. Medicamentul urmeaz\u0103 s\u0103 intre \u00een studii clinice de faz\u0103 III, ultima etap\u0103 \u00eenaintea unei eventuale aprob\u0103ri.<\/p>\n

Tratamente personalizate \u00een viitor<\/h2>\n

Cercet\u0103torii \u00eencearc\u0103 acum s\u0103 identifice biomarkeri care s\u0103 permit\u0103 depistarea timpurie a complica\u021biei \u0219i alegerea celui mai potrivit tratament. Primele rezultate sugereaz\u0103 c\u0103 nu exist\u0103 o singur\u0103 form\u0103 de ca\u0219exie, ci mai multe subtipuri, fiecare cu mecanisme diferite \u0219i care ar putea necesita terapii specifice.<\/p>\n

Speciali\u0219tii sunt optimi\u0219ti c\u0103, odat\u0103 cu noile descoperiri, aceast\u0103 complica\u021bie a cancerului nu va mai fi considerat\u0103 inevitabil\u0103. Dac\u0103 studiile aflate \u00een desf\u0103\u0219urare \u00ee\u0219i confirm\u0103 rezultatele, pacien\u021bii ar putea beneficia \u00een urm\u0103torii ani de primele tratamente capabile s\u0103 \u00eencetineasc\u0103 sau chiar s\u0103 previn\u0103 degradarea sever\u0103 a organismului provocat\u0103 de boal\u0103.<\/p>\n","protected":false},"excerpt":{"rendered":"

Cercet\u0103torii spun c\u0103 au f\u0103cut progrese importante \u00een \u00een\u021belegerea mecanismelor care provoac\u0103 aceast\u0103 afec\u021biune, iar primele medicamente dedicate au ajuns deja \u00een studii clinice avansate, se arat\u0103 \u00eentr-o analiz\u0103 publicat\u0103 … Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":704220,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/posts\/704219"}],"collection":[{"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=704219"}],"version-history":[{"count":0,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/posts\/704219\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=\/wp\/v2\/media\/704220"}],"wp:attachment":[{"href":"https:\/\/microscopemedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=704219"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=704219"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/microscopemedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=704219"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}